Teaching
BL2300 Research methods in biology
BL2301 Cell biology
BL2302 Molecular biology
BL3302 Gene regulation
BL4223 Molecular and cell biology of eukaryotic DNA replication
BL4201 Experimental research project
Research areas
Research in the MacNeill lab is primarily focused on dissecting the enzymes and mechanisms of听DNA replication and genome stability听using two contrasting genetically-tractable model systems, the eukaryotic fission yeast Schizosaccharomyces pombe听and the halophilic euryarchaeon Haloferax volcanii. In addition to this, we also study the molecular biology of T5-like bacteriophages, the activity of the highly diverged DNA ligase enzymes encoded by crAss-like bacteriophages and various eukaryotic viruses, such as Cedratvirus kamchatka, and the function of selected听carbohydrate-active enzymes (CAZymes) in Haloarcula hispanica, Haloferax volcanii听and related haloarchaea. In the past we have also worked on the parasitic protozoan听Trypanosoma brucei and the non-human infectious kinetoplastid model organism Crithidia fasciculata. We use a variety of methods to address questions of protein structure and function, including genetics, genome engineering, cell and molecular biology, biochemistry, structural biology and bioinformatics.
PhD supervision
- Liyuan听Chen
Selected publications
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Open access
MacNeill, S. A., Dec 2018, In: Emerging Topics in Life Sciences. 2, 4, p. 493-501
Research output: Contribution to journal 鈥� Review article 鈥� peer-review
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Open access
Giroux, X. & MacNeill, S., 22 Dec 2015, In: Molecular Microbiology. 99, 1, p. 1-14
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
Alphey, M. S., Wolford, C. & MacNeill, S., 18 Dec 2023, In: Frontiers in Molecular Biosciences. 10, 9 p., 1320648.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
MacNeill, S., 20 Jul 2021, In: Frontiers in Molecular Biosciences. 8, 8 p., 675229.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
Yang, D., Alphey, M. S. & MacNeill, S., 22 Aug 2022, (E-pub ahead of print) In: FEBS Journal. Early View, 14 p., 16590.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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