Research areas
Bacterial infections and the rise of antimicrobial resistance (AMR) are a significant global threat already involved in almost . Many bacterial pathogens harbour multiple mobile genetic elements (MGEs), which play a crucial role in their ability to cause disease. Many MGEs are known to interact with each other yet how more complex MGE interactions affect a pathogen’s success has not yet been determined. My research group tackles this challenge by investigating how interactions between MGEs in bacteria, particularly Staphylococcus aureus, influence their evolution, virulence, and ability to resist antibiotics, ultimately driving their success.
Our mission is to understand how MGEs collaborate and compete to shape bacterial pathogens, ultimately aiming to develop new strategies to combat infections.
We achieve this mission by:
- Characterising the molecular mechanisms underlying key MGE interactions.
- Defining the impact of MGE interactions on bacterial evolution and antibiotic resistance.
- Investigating how MGE interactions influence bacterial virulence and pathogenicity.
- Utilising our findings to develop novel treatment strategies against bacterial infections.
PhD supervision
- Lucy Wayne
Selected publications
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Open access
Rivas Ramos, J. E., Johnston, P. R., Hammond, R. J. H., Holden, M. T. G., Sloan, D. J. & Haag, A. F., 28 Jan 2026, In: Access Microbiology. 8, 1, p. 1-4 4 p., 001110.v3.
Research output: Contribution to journal › Article › peer-review
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Open access
Podkowik, M., Perault, A. I., Putzel, G., Pountain, A., Kim, J., DuMont, A. L., Zwack, E. E., Ulrich, R. J., Karagounis, T. K., Zhou, C., Haag, A. F., Shenderovich, J., Wasserman, G. A., Kwon, J., Chen, J., Richardson, A. R., Weiser, J. N., Nowosad, C. R., Lun, D. S. & Parker, D. & 6 others, , 30 Apr 2024, In: eLife. 12, 32 p., RP89098.
Research output: Contribution to journal › Article › peer-review
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Open access
Haag, A., Liljeroos, L., Donato, P., Pozzi, C., Brignoli, T., Bottomley, M. J., Bagnoli, F. & Delany, I., 1 Feb 2023, In: Microbiology Spectrum. 11, 1, 19 p., e02574-22.
Research output: Contribution to journal › Article › peer-review
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Open access
Podkowik, M., Perault, A. I., Putzel, G., Pountain, A., Kim, J., DuMont, A., Zwack, E., Ulrich, R. J., Karagounis, T. K., Zhou, C., Haag, A. F., Shenderovich, J., Wasserman, G. A., Kwon, J., Chen, J., Richardson, A. R., Weiser, J. N., Nowosad, C. R., Lun, D. S. & Zhao, X. & 7 others, , 8 Jun 2023, bioRxiv, 64 p.
Research output: Working paper › Preprint
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Bagnoli, F., Haag, A. & Liljeroos, L., 1 Feb 2023, Google Patents.
Research output: Other contribution
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Open access
Thabet, M. A., Penades, J. R. & Haag, A., 18 Oct 2023, In: Nature Communications. 14, 16 p., 6599.
Research output: Contribution to journal › Article › peer-review
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Open access
Borghi, S., Antunes, A., Haag, A. F., Spinsanti, M., Brignoli, T., Ndoni, E., Scarlato, V. & Delany, I., 18 Apr 2022, In: Microorganisms. 10, 4, 16 p., 834.
Research output: Contribution to journal › Article › peer-review
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Open access
Ibarra-Chávez, R., Brady, A., Chen, J., Penadés, J. R. & Haag, A. F., 28 Mar 2022, In: PLoS Genetics. 18, 3, 18 p., e1010146.
Research output: Contribution to journal › Article › peer-review
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Open access
Haag, A. F., Podkowik, M., Ibarra-Chávez, R., del Sol, F. G., Ram, G., Chen, J., Marina, A., Novick, R. P. & Penadés, J. R., 27 May 2022. 1 p.
Research output: Contribution to conference › Poster
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Pickering, A. C., Haag, A. F., Penades, J. R. & Fitzgerald, J. R., 1 Dec 2022, Pathogenesis of bacterial infections in animals. Prescott, J. F., Rycroft, A. N., Boyce, J. D., MacInnes, J. I., Van Immerseel, F. & Vázquez-Boland, J. A. (eds.). 5th ed. Chichester: John Wiley & Sons, Ltd, p. 543-564 22 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter