Research areas
We are interested in the use and development of novel biophysical techniques to study biomolecular interactions including proteins, DNA and RNA at the level of individual molecules. The advantages of single-molecule detection are many, apart from the fascination of looking at individual biomolecules at work, single-molecule techniques can measure intermediates and follow time-dependent pathways of chemical reactions and folding mechanisms that are difficult or impossible to synchronize at the ensemble level. Thus, single-molecule techniques provide novel insights into how molecules and systems behave, having the advantage that spatial and temporal averaging is avoided, temporal synchronisation is not necessary and novel phenomena, which otherwise are averaged and remain hidden in ensembles, may be discovered. Our aim is to monitor, in real-time, the behaviour of individual biological molecules and complexes, in vitro and in live cells. By combining the dynamic information obtained at the single-molecule or single-complex level with structural and biochemical analyses, we hope to create "molecular movies" of biological processes and from them obtain a deeper understanding of these processes.
PhD supervision
- Olga听Filippova
- Aakanksha听J Shetty
- Amirmohammad听Khodabandeh
- George听Kingsley-Moore
- Timothy听Redpath
- Ghazal听Sharifian
- Yu听Sun
Selected publications
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Open access
Hartman, R., Blane, A., Kubrom, F., Mayet, R., Penedo, J. C. & Fanucchi, S., 15 Jan 2026, In: Journal of Molecular Biology. 438, 2, p. 1-23 23 p., 169543.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
Burkhart, I., Limmer, M., Penedo , J. C., Sauer, L.-C., Schwalbe, H. & Paeschke, K., 11 Nov 2025, In: Nucleic Acids Research. 53, 20, 15 p., gkaf1055.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Penedo , J. C., 1 May 2025, In: Nature Nanotechnology. 19, 5, p. 580-581 2 p.
Research output: Contribution to journal 鈥� Comment/debate 鈥� peer-review
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Open access
Hien, E. D. M., St-Pierre, P., Carlos Penedo, J. & Lafontaine, D. A., 15 Nov 2024, In: Journal of Molecular Biology. 436, 22, 15 p., 168771.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
Grondin, J. P., Geffroy, M., Simoneau-Roy, M., Chauvier, A., Turcotte, P., St-Pierre, P., Dub茅, A., Moreau, J., Mass茅, E., Penedo, J. C. & Lafontaine, D. A., 17 Oct 2024, In: Communications Biology. 7, 10 p., 1345.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
Dresser, L. G., Kunstmann-Olsen, C., Conteduca, D., Hofmair, C. M., Smith, N., Clark, L., Johnson, S., Penedo, J. C., Leake, M. C. & Quinn, S. D., 19 Sept 2024, In: Communications Materials. 5, 12 p., 195.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
Komaniecka, N., Porras, M., Cairn, L., Santas, J. A., Ferreiro, N., Penedo , C. & Banuelos, S., 20 Jul 2022, In: International Journal of Molecular Sciences. 23, 14, 14 p., 8015.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
St-Pierre, P., Shaw, E. S., Jacques, S., Dalgarno, P. A., Perez Gonzalez, C., Picard-Jean, F., Penedo , C. & Lafontaine, D. A., 8 May 2021, (E-pub ahead of print) In: Nucleic Acids Research. Advance Article, 14 p.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
Arya, S., Gourley, A. J., Penedo , J. C., Blindauer, C. A. & Stewart, A. J., 21 Nov 2021, In: BioEssays. 43, 12, 9 p., 202100172.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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Open access
Chauvier, A., St-Pierre, P., Nadon, J.-F., Hien, E., Perez Gonzalez, D. C., Eschbach, S. H., Lamontagne, A.-M., Penedo , C. & Lafontaine, D. A., 9 Nov 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 45, 11 p., e2116155118.
Research output: Contribution to journal 鈥� Article 鈥� peer-review
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